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Symbol Name ID |
Bmpr2
bone morphogenetic protein receptor type 2 MGI:1095407 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Right ventricular dilatation |
Right ventricular hypertrophy |
Pulmonary arterial medial hypertrophy |
Pulmonary aterial intimal fibrosis |
Pulmonary venous occlusion |
Arterial intimal fibrosis |
Abnormal cardiovascular system physiology |
Elevated right atrial pressure |
Right ventricular failure |
Abnormally loud pulmonic component of the second heart sound |
Heart murmur |
Tricuspid regurgitation |
Hypertension |
Elevated pulmonary artery pressure |
Pulmonary arterial hypertension |
Pulmonary arterial hypertension with lack of acute response to NO challenge |
Increased pulmonary vascular resistance |
Elevated jugular venous pressure |
Palpitations |
Atrial flutter |
First degree atrioventricular block |
Right bundle branch block |
Angina pectoris |
Syncope |
Pulmonary artery vasoconstriction |
Telangiectasia |
| Disease(s) Associated with BMPR2 | ||||||||||||||||||||||||||
| primary pulmonary hypertension | ||||||||||||||||||||||||||
| pulmonary venoocclusive disease 1 |
| Mouse Phenotypes | cardiovascular system phenotype |
abnormal blood vessel morphology |
abnormal pulmonary artery morphology |
interrupted aortic arch |
artery occlusion |
abnormal lung vasculature morphology |
decreased angiogenesis |
absent vitelline blood vessels |
vascular smooth muscle hypoplasia |
abnormal myocardium compact layer morphology |
heart right ventricle hypertrophy |
persistent truncus arteriosus type i |
persistent truncus arteriosus type iv |
atrioventricular septal defect |
abnormal interventricular septum morphology |
muscular ventricular septal defect |
abnormal semilunar valve morphology |
increased pulmonary vascular resistance |
gastrointestinal hemorrhage |
intestinal hemorrhage |
increased right ventricle systolic pressure |
increased pulmonary artery pressure |
pulmonary hypertension |
increased vascular permeability |
increased vascular smooth muscle cell proliferation |
increased vasoconstriction |
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| Availability | Mouse Genotype | ||||||||||||||||||||||||||
| Bmpr2b2b2556Clo/Bmpr2b2b2556Clo | |||||||||||||||||||||||||||
| Bmpr2tm1Kml/Bmpr2tm1Kml | |||||||||||||||||||||||||||
| Gt(ROSA)26Sortm1(RNAi:Bmpr2)Dliu/Gt(ROSA)26Sortm1(RNAi:Bmpr2)Dliu | |||||||||||||||||||||||||||
| Bmpr2tm1.1Pley/Bmpr2+ | * | ||||||||||||||||||||||||||
| Bmpr2tm1Kmi/Bmpr2+ | |||||||||||||||||||||||||||
| Bmpr2tm1Mmue/Bmpr2+ | |||||||||||||||||||||||||||
| Gt(ROSA)26Sortm1(RNAi:Bmpr2)Dliu/Gt(ROSA)26Sor+ | |||||||||||||||||||||||||||
| Tg(Tagln-rtTA)E1Jwst/0 Tg(tetO-Bmpr2*R899X)#Jwst/0 |
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| Bmpr2tm1.1Enl/Bmpr2tm1.1Enl Tg(Acvrl1-cre)L1Spo/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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